---
title: "159 Seed Biotech Investors in the US (Nov 2026)"
last_updated: "2026-11-06"
rows: "159"
free_rows: "25"
source: "SEC filings"
canonical: "https://theinvestordatabase.com/lists/seed-biotech-investors-us/"
---

# 159 seed biotech investors in the US

We list 159 seed biotech investors in the US as of November 2026: each has an SEC filing on file, and the list was last checked on 6 Nov 2026. The cities with the most head offices on this list are San Francisco (15), New York (10) and Palo Alto (10).

- 159 investors
- 84 with a fund filing or dated deal in the last 12 months
- $70M median fund size on file (SEC Form D, 111 firms)
- 838 named decision-makers on file

## First 25 of 159 seed biotech investors in the US

| Investor | Type | HQ | Stages (our research) | Focus (our research) | Latest fund or deal | Fund size | Checked | Profile |
|---|---|---|---|---|---|---|---|---|
| Hatteras Venture Partners | VC firm | Durham, NC | Seed | Biotech, Healthtech, Medtech | New fund, Oct 2026 | $250M (SEC Form D, 2023) | 2026-11-04 | https://theinvestordatabase.com/investors/hatteras-venture-partners/ |
| Digitalis Ventures | VC firm | New York, NY | Seed | Biotech, Healthtech, Medtech | Portfolio news, Nov 2026 | $862M (SEC Form ADV) | 2026-11-05 | https://theinvestordatabase.com/investors/digitalis-ventures/ |
| Gore Range Capital | VC firm | Southlake, TX | Seed | Biotech, Healthtech, Medtech | New deal, Aug 2026 | $250M (SEC Form D, 2026) | 2026-11-04 | https://theinvestordatabase.com/investors/gore-range-capital/ |
| Narya | VC firm | Columbus, OH | Seed | Biotech, Fintech, Healthtech, Defense Tech | New fund, Sep 2026 | $200M (SEC Form D, 2026) | 2026-11-04 | https://theinvestordatabase.com/investors/narya/ |
| First In Ventures | VC firm | Hobe Sound, FL | Pre-seed, Seed | Biotech, Healthtech, AI, Climate Tech | New fund, Sep 2026 | $22M (SEC Form D, 2026) | 2026-11-04 | https://theinvestordatabase.com/investors/first-in-ventures/ |
| Safar Partners | VC firm | Cambridge, MA | Seed | Biotech, Healthtech, Industrial Tech, Deep Tech | New deal, Aug 2026 | $300M (SEC Form D, 2023) | 2026-11-04 | https://theinvestordatabase.com/investors/safar-partners/ |
| NSV | VC firm | Greenwich, CT | Seed, Late stage | Biotech, Healthtech, AI, Semiconductor | Portfolio news, Oct 2026 | $990M (SEC Form ADV) | 2026-11-05 | https://theinvestordatabase.com/investors/nsv/ |
| Future Ventures | VC firm | Los Altos, CA | Seed | Biotech, Healthtech, AI, Energy | New fund, Oct 2026 | $200M (SEC Form D, 2021) | 2026-11-04 | https://theinvestordatabase.com/investors/future-ventures/ |
| Madrona | VC firm | Seattle, WA | Pre-seed, Seed, Series A, Series B, Growth | Biotech, AI, Consumer, Deep Tech | New deal, Oct 2026 | $490M (SEC Form D, 2025) | 2026-11-05 | https://theinvestordatabase.com/investors/madrona/ |
| ARCH Venture Partners | VC firm | Chicago, IL | Pre-seed, Seed | Biotech, Healthtech, Deep Tech | New fund, Aug 2026 | $3.0B (SEC Form D, 2024) | 2026-11-04 | https://theinvestordatabase.com/investors/arch-venture-partners/ |
| Refactor Capital | VC firm | Burlingame, CA | Seed | Biotech, AI, Healthtech, Energy | New fund, May 2026 | $50M (SEC Form D, 2021) | 2026-11-04 | https://theinvestordatabase.com/investors/refactor-capital/ |
| Prevail Venture Capital | VC firm | Leawood, KS | Seed | Biotech, Healthtech, Defense Tech, Fintech | New fund, Jul 2026 | $100M (SEC Form D, 2025) | 2026-11-04 | https://theinvestordatabase.com/investors/prevail-venture-capital/ |
| Bison Ventures | VC firm | San Francisco, CA | Pre-seed, Seed, Series A, Series B | Biotech, AI, Healthtech, Energy | New fund, Oct 2026 | $160M (SEC Form D, 2025) | 2026-11-04 | https://theinvestordatabase.com/investors/bison-ventures/ |
| Suncoast Ventures | VC firm | Walnut Creek, CA | Seed | Biotech, Healthtech, Medtech | New fund, Jul 2026 | $15M (SEC Form D, 2022) | 2026-11-04 | https://theinvestordatabase.com/investors/suncoast-ventures/ |
| True Ventures | VC firm | Palo Alto, CA | Pre-seed, Seed | Biotech, AI, Fintech, Deep Tech | New fund, Sep 2026 | $800M (SEC Form D, 2022) | 2026-11-04 | https://theinvestordatabase.com/investors/true-ventures/ |
| Felicis | VC firm | Menlo Park, CA | Seed, Series A | Biotech, AI, Developer Tools, Healthtech | New deal, Oct 2026 | $900M (SEC Form D, 2025) | 2026-11-05 | https://theinvestordatabase.com/investors/felicis/ |
| Breakout Ventures | VC firm | San Francisco, CA | Seed | Biotech, AI, Healthtech, Industrial Tech | New deal, Jun 2026 | $112M (SEC Form D, 2021) | 2026-11-04 | https://theinvestordatabase.com/investors/breakout-ventures/ |
| DeepWork Capital | VC firm | Orlando, FL | Seed, Series A | Biotech, Healthtech, Fintech, AI | New deal, Jun 2026 | $100M (SEC Form D, 2023) | 2026-11-05 | https://theinvestordatabase.com/investors/deepwork-capital/ |
| Aisling Capital | VC firm | New York, NY | Seed | Biotech, Healthtech, Food and Beverage, Medtech | Portfolio news, Jul 2026 | $64M (SEC Form ADV) | 2026-11-05 | https://theinvestordatabase.com/investors/aisling-capital/ |
| Union Square Ventures | VC firm | New York, NY | Seed, Series A | Biotech, AI, Generalist, Robotics | New deal, Oct 2026 | $3M (SEC Form D, 2026) | 2026-11-04 | https://theinvestordatabase.com/investors/union-square-ventures/ |
| PsyMed Ventures | VC firm | Tahoma, CA | Seed | Biotech, Healthtech, AI, Medtech | New fund, Jun 2025 | $25M (SEC Form D, 2025) | 2026-11-05 | https://theinvestordatabase.com/investors/psymed-ventures/ |
| 2048 Ventures | VC firm | Princeton, NJ | Pre-seed, Seed | Biotech, AI, Deep Tech, Healthtech | New deal, Jun 2026 | $82M (SEC Form D, 2025) | 2026-11-04 | https://theinvestordatabase.com/investors/2048-ventures/ |
| Two Bear Capital | VC firm | Whitefish, MT | Seed | Biotech, Healthtech, AI, Deep Tech | New fund, May 2026 | $123M (SEC Form D, 2025) | 2026-11-04 | https://theinvestordatabase.com/investors/two-bear-capital/ |
| Crossroads Health Ventures | VC firm | Indianapolis, IN | Seed | Biotech, Healthtech | New fund, Feb 2026 | $100M (SEC Form D, 2026) | 2026-11-04 | https://theinvestordatabase.com/investors/crossroads-health-ventures/ |
| Cybernetix Ventures | VC firm | Boston, MA | Pre-seed, Seed, Series A | Biotech, Robotics, Industrial Tech, Logistics | New fund, Aug 2026 | $100M (SEC Form D, 2025) | 2026-11-04 | https://theinvestordatabase.com/investors/cybernetix-ventures/ |

You are seeing 25 of 159. The full list adds 134 more investors and 838 named decision-makers.

Get all 159 investors and 838 named contacts, $49, one-time: https://theinvestordatabase.com/buy/list/seed-biotech-investors-us
This page: https://theinvestordatabase.com/lists/seed-biotech-investors-us/

## Method and limits
- Source: All 159 rows carry an SEC filing (Form D or Form ADV). All 159 have a website we checked. Filing date and fund size are SEC data where a filing exists. Stage, sector and check size are our research.
- Inclusion rule: Organizations that back startups. Individuals, buyout funds and firms we found to be inactive are left out. Sector: the firm states biotech and life sciences as a focus on its own site, or we observed it in the firm's portfolio. Stage: the firm states that it invests at seed.
- Order: Activity score out of 100: recency of the latest fund filing or dated deal (30: full marks within 3 months, then stepping down at 6, 12 and 24 months), share of the observed portfolio in this sector (20; half of that when the sector is stated only), stage focus (15: all of it when seed is the only stage the firm states, split evenly when it states more), stated focus on the US (15: full marks when the firm names the US as where it invests, half when it says global), size of the fund on file on a log scale (12) and completeness of the public record (8). Stage and regional focus are our research, not an SEC figure. It is a measure of activity and fit, not of quality or returns.
- Fill rates: Of 159 rows: stage 159, sector 159, fund size 143, website 159. In the paid file: named decision-makers on 154 rows, firm email on 47, LinkedIn page on 81, check size on 11.

## Questions
### How many seed biotech investors in the US are there?
We list 159 as of November 2026. 84 of the 159 have a fund filing or a dated deal in the last 12 months. The cities with the most are San Francisco (15), New York (10) and Palo Alto (10).

### Which seed biotech investors in the US raised a new fund in the last 12 months?
58 of the 159 have a fund filing dated in the last 12 months. The most recent on this list are Future Ventures (Oct 2026), Draper Associates (Oct 2026) and Pear Ventures (Oct 2026).

### What is the typical fund size of seed biotech investors in the US?
The median fund size on file for this list is $70M, across the 111 firms with a size on an SEC Form D. The fund on file is each firm's main fund, which is not always its newest. The other 48 do not disclose a size there.

### How do I contact seed biotech investors in the US?
The paid file holds 838 named decision-makers across 154 of these 159 and a firm email for 47. We publish the address a firm lists itself, never a personal email. Each free row links to a profile with the firm's website.

### Where does the data on seed biotech investors in the US come from?
All 159 rows have an SEC filing on file (Form D or Form ADV). Filing date and fund size come from the filing. Stage, sector and check size are our research. Rows on this list were last checked on 6 Nov 2026 at the latest. The whole file is re-verified twice a year.