81 pre-seed biotech investors in the US
We list 81 pre-seed biotech investors in the US as of November 2026: each has an SEC filing on file, and the list was last checked on 6 Nov 2026. The cities with the most head offices on this list are Boston (9), San Francisco (7) and Palo Alto (6).
Top 5 pre-seed biotech investors in the US, ranked by recent fund activity
Among firms with a published profile and a dated fund or deal in the last 24 months. The rule: Activity score out of 100: recency of the latest fund filing or dated deal (30: full marks within 3 months, then stepping down at 6, 12 and 24 months), share of the observed portfolio in this sector (20; half of that when the sector is stated only), stage focus (15: all of it when pre-seed is the only stage the firm states, split evenly when it states more), stated focus on the US (15: full marks when the firm names the US as where it invests, half when it says global), size of the fund on file on a log scale (12) and completeness of the public record (8). Stage and regional focus are our research, not an SEC figure. It is a measure of activity and fit, not of quality or returns. The same rule orders the whole list; it is repeated in the method box.
SOSV
Type: VC firm · HQ: United States · Stages: Pre-seed · Focus: Biotech, Deep Tech, Climate Tech, Healthtech · Latest activity: Portfolio news, Nov 2026 · Fund size on file: $131M (SEC Form D, 2022)
Portfolio news dated Nov 2026; $131M fund on file (SEC Form D, 2022); states biotech and life sciences as a focus; backs pre-seed; names the US as where it invests; 8 named decision-makers on file.
First In Ventures
Type: VC firm · HQ: Hobe Sound, FL · Stages: Pre-seed, Seed · Focus: Biotech, Healthtech, AI, Climate Tech · Latest activity: New fund, Sep 2026 · Fund size on file: $22M (SEC Form D, 2026)
Latest fund filing dated Sep 2026; $22M fund on file (SEC Form D, 2026); 69% of its observed portfolio is biotech and life sciences; backs pre-seed, seed; names the US as where it invests; 5 named decision-makers on file.
Transpose Platform
Type: VC firm · HQ: Houston, TX · Stages: Pre-seed · Focus: Biotech, AI, Generalist · Latest activity: New fund, Sep 2026 · Fund size on file: $500M (SEC Form D, 2026)
Latest fund filing dated Sep 2026; $500M fund on file (SEC Form D, 2026); states biotech and life sciences as a focus; backs pre-seed; 8 named decision-makers on file.
Madrona
Type: VC firm · HQ: Seattle, WA · Stages: Pre-seed, Seed, Series A, Series B, Growth · Focus: Biotech, AI, Consumer, Deep Tech · Latest activity: New deal, Oct 2026 · Fund size on file: $490M (SEC Form D, 2025)
Dated new deal in Oct 2026; $490M fund on file (SEC Form D, 2025); states biotech and life sciences as a focus; backs pre-seed, seed, Series A; names the US as where it invests; 8 named decision-makers on file.
ARCH Venture Partners
Type: VC firm · HQ: Chicago, IL · Stages: Pre-seed, Seed · Focus: Biotech, Healthtech, Deep Tech · Latest activity: New fund, Aug 2026 · Fund size on file: $3.0B (SEC Form D, 2024)
Latest fund filing dated Aug 2026; $3.0B fund on file (SEC Form D, 2024); 81% of its observed portfolio is biotech and life sciences; backs pre-seed, seed; 8 named decision-makers on file.
First 25 of 81 pre-seed biotech investors in the US
| Investor | Type | HQ | Stagesour research | Focusour research | Latest fund or deal | Fund sizeas filed or stated | Checked | Contacts |
|---|---|---|---|---|---|---|---|---|
| SOSV | VC firm | United States | Pre-seed | Biotech, Deep Tech, Climate Tech, Healthtech | Portfolio news, Nov 2026 | $131M (SEC Form D, 2022) | 4 Nov 2026 | 8 names · Unlock |
| First In Ventures | VC firm | Hobe Sound, FL | Pre-seed, Seed | Biotech, Healthtech, AI, Climate Tech | New fund, Sep 2026 | $22M (SEC Form D, 2026) | 4 Nov 2026 | 5 names, firm email · Unlock |
| Transpose Platform | VC firm | Houston, TX | Pre-seed | Biotech, AI, Generalist | New fund, Sep 2026 | $500M (SEC Form D, 2026) | 4 Nov 2026 | 8 names · Unlock |
| Madrona | VC firm | Seattle, WA | Pre-seed, Seed, Series A, Series B, Growth | Biotech, AI, Consumer, Deep Tech | New deal, Oct 2026 | $490M (SEC Form D, 2025) | 5 Nov 2026 | 8 names · Unlock |
| ARCH Venture Partners | VC firm | Chicago, IL | Pre-seed, Seed | Biotech, Healthtech, Deep Tech | New fund, Aug 2026 | $3.0B (SEC Form D, 2024) | 4 Nov 2026 | 8 names · Unlock |
| Bison Ventures | VC firm | San Francisco, CA | Pre-seed, Seed, Series A, Series B | Biotech, AI, Healthtech, Energy | New fund, Oct 2026 | $160M (SEC Form D, 2025) | 4 Nov 2026 | 2 names, firm email · Unlock |
| Avalon BioVentures | VC firm | La Jolla, CA | Pre-seed | Biotech, Healthtech, Space | Portfolio news, Nov 2024 | $200M (SEC Form D, 2021) | 5 Nov 2026 | 8 names, firm email · Unlock |
| True Ventures | VC firm | Palo Alto, CA | Pre-seed, Seed | Biotech, AI, Fintech, Deep Tech | New fund, Sep 2026 | $800M (SEC Form D, 2022) | 4 Nov 2026 | 8 names · Unlock |
| 2048 Ventures | VC firm | Princeton, NJ | Pre-seed, Seed | Biotech, AI, Deep Tech, Healthtech | New deal, Jun 2026 | $82M (SEC Form D, 2025) | 4 Nov 2026 | 8 names · Unlock |
| Cybernetix Ventures | VC firm | Boston, MA | Pre-seed, Seed, Series A | Biotech, Robotics, Industrial Tech, Logistics | New fund, Aug 2026 | $100M (SEC Form D, 2025) | 4 Nov 2026 | 2 names · Unlock |
| Thirdrockventures | VC firm | Boston, MA | Pre-seed, Seed | Biotech, Healthtech, Medtech | New fund, Jun 2026 | $1.1B (SEC Form D, 2022) | 4 Nov 2026 | 8 names · Unlock |
| Column Group | VC firm | San Francisco, CA | Pre-seed | Biotech, Healthtech | New deal, Jan 2026 | $600M (SEC Form D, 2022) | 4 Nov 2026 | 8 names, firm email · Unlock |
| How Women Invest | VC firm | Oakland, CA | Pre-seed, Seed, Series A, Series B | Biotech, Healthtech, AI, B2B | New fund, Sep 2026 | $12M (SEC Form D, 2026) | 4 Nov 2026 | 8 names · Unlock |
| Atlas Venture | VC firm | Cambridge, MA | Pre-seed | Biotech, Healthtech | New deal, Jan 2026 | $450M (SEC Form D, 2022) | 4 Nov 2026 | 5 names · Unlock |
| Mission BioCapital | VC firm | Cambridge, MA | Pre-seed | Biotech, Healthtech, Medtech | New fund, Apr 2026 | $192M (SEC Form D, 2021) | 4 Nov 2026 | 8 names, firm email · Unlock |
| Voltage Ventures | VC firm | Portland, ME | Pre-seed | Biotech, Healthtech, Medtech | New fund, Jul 2026 | $18M (SEC Form D, 2026) | 4 Nov 2026 | 4 names · Unlock |
| Hyve Ventures | VC firm | Austin, TX | Pre-seed | Biotech, Consumer, Healthtech, Logistics | New fund, Nov 2026 | $6M (SEC Form D, 2025) | 4 Nov 2026 | 1 name · Unlock |
| Monograph Capital | VC firm | Fort Worth, TX | Pre-seed | Biotech, Healthtech | New deal, Jun 2026 | $326M (SEC Form ADV) | 5 Nov 2026 | 8 names, firm email · Unlock |
| 3i Partners | VC firm | Los Altos, CA | Pre-seed, Seed | Biotech, Mobility, Healthtech, Deep Tech | New fund, May 2026 | $24M (SEC Form D, 2025) | 5 Nov 2026 | 8 names · Unlock |
| Draper Associates | VC firm | San Mateo, CA | Pre-seed, Seed, Series A | Biotech, AI, Fintech, Healthtech | New fund, Oct 2026 | $301M (SEC Form D, 2025) | 4 Nov 2026 | 8 names · Unlock |
| Even One Ventures | VC firm | San Francisco, CA | Pre-seed | Biotech, Healthtech, Medtech | New fund, Feb 2026 | $20M (SEC Form D, 2026) | 4 Nov 2026 | 8 names · Unlock |
| Cure Ventures | VC firm | Boston, MA | Pre-seed, Seed | Biotech, Healthtech | New fund, Dec 2025 | $350M (SEC Form D, 2021) | 4 Nov 2026 | 8 names, firm email · Unlock |
| K5 Global | VC firm | Miami Beach, FL | Pre-seed, Growth, Any stage | Biotech, AI, Fintech, Healthtech | New fund, Oct 2026 | $10M (SEC Form D, 2026) | 4 Nov 2026 | 8 names, firm email · Unlock |
| Averin | VC firm | Andover, MA | Pre-seed | Biotech, Healthtech, AI, Robotics | New fund, Mar 2026 | $350M (SEC Form D, 2026) | 4 Nov 2026 | 7 names · Unlock |
| Kapor Capital | VC firm | Oakland, CA | Pre-seed, Seed, Series A | Biotech, Edtech, Fintech, Healthtech | New deal, Jun 2026 | $125M (SEC Form D, 2021) | 5 Nov 2026 | 5 names · Unlock |
You are seeing 25 of 81. The full list adds 56 more investors and 438 named decision-makers.
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How these 81 break down
By US state
| US state | On this list | Share |
|---|---|---|
| California | 34 | 42% |
| Massachusetts | 13 | 16% |
| Texas | 7 | 9% |
| New York | 6 | 7% |
| Florida | 3 | 4% |
| Washington | 2 | 2% |
| New Jersey | 2 | 2% |
| Oregon | 2 | 2% |
By type
| Type | On this list | Share |
|---|---|---|
| VC firm | 79 | 98% |
| Accelerator | 2 | 2% |
Method and limits
- Source
- All 81 rows carry an SEC filing (Form D or Form ADV). All 81 have a website we checked. Filing date and fund size are SEC data where a filing exists. Stage, sector and check size are our research.
- Inclusion rule
- Organizations that back startups. Individuals, buyout funds and firms we found to be inactive are left out. Sector: the firm states biotech and life sciences as a focus on its own site, or we observed it in the firm's portfolio. Stage: the firm states that it invests at pre-seed.
- Order
- Firms with a published profile come first. Activity score out of 100: recency of the latest fund filing or dated deal (30: full marks within 3 months, then stepping down at 6, 12 and 24 months), share of the observed portfolio in this sector (20; half of that when the sector is stated only), stage focus (15: all of it when pre-seed is the only stage the firm states, split evenly when it states more), stated focus on the US (15: full marks when the firm names the US as where it invests, half when it says global), size of the fund on file on a log scale (12) and completeness of the public record (8). Stage and regional focus are our research, not an SEC figure. It is a measure of activity and fit, not of quality or returns.
- Last refreshed
- November 2026. Rows on this list were checked between 4 Nov 2026 and 6 Nov 2026.
- Fill rates
- Of 81 rows: stage 81, sector 81, fund size 70, website 81. In the paid file: named decision-makers on 80 rows, firm email on 26, LinkedIn page on 45, check size on 7.
- Corrections
- Email hello@theinvestordatabase.com or use the update form. We act within 5 working days.
Questions
How many pre-seed biotech investors in the US are there?
We list 81 as of November 2026. 50 of the 81 have a fund filing or a dated deal in the last 12 months. The cities with the most are Boston (9), San Francisco (7) and Palo Alto (6).
Which pre-seed biotech investors in the US raised a new fund in the last 12 months?
40 of the 81 have a fund filing dated in the last 12 months. The most recent on this list are Hyve Ventures (Nov 2026), Draper Associates (Oct 2026) and Pear Ventures (Oct 2026).
What is the typical fund size of pre-seed biotech investors in the US?
The median fund size on file for this list is $73M, across the 58 firms with a size on an SEC Form D. The fund on file is each firm's main fund, which is not always its newest. The other 23 do not disclose a size there.
How do I contact pre-seed biotech investors in the US?
The paid file holds 438 named decision-makers across 80 of these 81 and a firm email for 26. We publish the address a firm lists itself, never a personal email. Each free row links to a profile with the firm's website.
Where does the data on pre-seed biotech investors in the US come from?
All 81 rows have an SEC filing on file (Form D or Form ADV). Filing date and fund size come from the filing. Stage, sector and check size are our research. Rows on this list were last checked on 6 Nov 2026 at the latest. The whole file is re-verified twice a year.
Broader lists
Biotech venture capital firms in the US (297)Pre-seed investors in the US (549)Pre-seed biotech investors (148)
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