159 seed biotech investors in the US
We list 159 seed biotech investors in the US as of November 2026: each has an SEC filing on file, and the list was last checked on 6 Nov 2026. The cities with the most head offices on this list are San Francisco (15), New York (10) and Palo Alto (10).
Top 5 seed biotech investors in the US, ranked by recent fund activity
Among firms with a published profile and a dated fund or deal in the last 24 months. The rule: Activity score out of 100: recency of the latest fund filing or dated deal (30: full marks within 3 months, then stepping down at 6, 12 and 24 months), share of the observed portfolio in this sector (20; half of that when the sector is stated only), stage focus (15: all of it when seed is the only stage the firm states, split evenly when it states more), stated focus on the US (15: full marks when the firm names the US as where it invests, half when it says global), size of the fund on file on a log scale (12) and completeness of the public record (8). Stage and regional focus are our research, not an SEC figure. It is a measure of activity and fit, not of quality or returns. The same rule orders the whole list; it is repeated in the method box.
Hatteras Venture Partners
Type: VC firm · HQ: Durham, NC · Stages: Seed · Focus: Biotech, Healthtech, Medtech · Latest activity: New fund, Oct 2026 · Fund size on file: $250M (SEC Form D, 2023)
Latest fund filing dated Oct 2026; $250M fund on file (SEC Form D, 2023); 62% of its observed portfolio is biotech and life sciences; backs seed; names the US as where it invests; 8 named decision-makers on file.
Digitalis Ventures
Type: VC firm · HQ: New York, NY · Stages: Seed · Focus: Biotech, Healthtech, Medtech · Latest activity: Portfolio news, Nov 2026 · Private fund assets: $862M (SEC Form ADV)
Portfolio news dated Nov 2026; $862M on file (SEC Form ADV); states biotech and life sciences as a focus; backs seed; names the US as where it invests; 8 named decision-makers on file.
Gore Range Capital
Type: VC firm · HQ: Southlake, TX · Stages: Seed · Focus: Biotech, Healthtech, Medtech · Latest activity: New deal, Aug 2026 · Fund size on file: $250M (SEC Form D, 2026)
Dated new deal in Aug 2026; $250M fund on file (SEC Form D, 2026); states biotech and life sciences as a focus; backs seed; names the US as where it invests; 1 named decision-maker on file.
Narya
Type: VC firm · HQ: Columbus, OH · Stages: Seed · Focus: Biotech, Fintech, Healthtech, Defense Tech · Latest activity: New fund, Sep 2026 · Fund size on file: $200M (SEC Form D, 2026)
Latest fund filing dated Sep 2026; $200M fund on file (SEC Form D, 2026); 25% of its observed portfolio is biotech and life sciences; backs seed; names the US as where it invests; 1 named decision-maker on file.
First In Ventures
Type: VC firm · HQ: Hobe Sound, FL · Stages: Pre-seed, Seed · Focus: Biotech, Healthtech, AI, Climate Tech · Latest activity: New fund, Sep 2026 · Fund size on file: $22M (SEC Form D, 2026)
Latest fund filing dated Sep 2026; $22M fund on file (SEC Form D, 2026); 69% of its observed portfolio is biotech and life sciences; backs pre-seed, seed; names the US as where it invests; 5 named decision-makers on file.
First 25 of 159 seed biotech investors in the US
| Investor | Type | HQ | Stagesour research | Focusour research | Latest fund or deal | Fund sizeas filed or stated | Checked | Contacts |
|---|---|---|---|---|---|---|---|---|
| Hatteras Venture Partners | VC firm | Durham, NC | Seed | Biotech, Healthtech, Medtech | New fund, Oct 2026 | $250M (SEC Form D, 2023) | 4 Nov 2026 | 8 names · Unlock |
| Digitalis Ventures | VC firm | New York, NY | Seed | Biotech, Healthtech, Medtech | Portfolio news, Nov 2026 | $862M (SEC Form ADV) | 5 Nov 2026 | 8 names, firm email · Unlock |
| Gore Range Capital | VC firm | Southlake, TX | Seed | Biotech, Healthtech, Medtech | New deal, Aug 2026 | $250M (SEC Form D, 2026) | 4 Nov 2026 | 1 name, firm email · Unlock |
| Narya | VC firm | Columbus, OH | Seed | Biotech, Fintech, Healthtech, Defense Tech | New fund, Sep 2026 | $200M (SEC Form D, 2026) | 4 Nov 2026 | 1 name · Unlock |
| First In Ventures | VC firm | Hobe Sound, FL | Pre-seed, Seed | Biotech, Healthtech, AI, Climate Tech | New fund, Sep 2026 | $22M (SEC Form D, 2026) | 4 Nov 2026 | 5 names, firm email · Unlock |
| Safar Partners | VC firm | Cambridge, MA | Seed | Biotech, Healthtech, Industrial Tech, Deep Tech | New deal, Aug 2026 | $300M (SEC Form D, 2023) | 4 Nov 2026 | 3 names, firm email · Unlock |
| NSV | VC firm | Greenwich, CT | Seed, Late stage | Biotech, Healthtech, AI, Semiconductor | Portfolio news, Oct 2026 | $990M (SEC Form ADV) | 5 Nov 2026 | 5 names · Unlock |
| Future Ventures | VC firm | Los Altos, CA | Seed | Biotech, Healthtech, AI, Energy | New fund, Oct 2026 | $200M (SEC Form D, 2021) | 4 Nov 2026 | 4 names · Unlock |
| Madrona | VC firm | Seattle, WA | Pre-seed, Seed, Series A, Series B, Growth | Biotech, AI, Consumer, Deep Tech | New deal, Oct 2026 | $490M (SEC Form D, 2025) | 5 Nov 2026 | 8 names · Unlock |
| ARCH Venture Partners | VC firm | Chicago, IL | Pre-seed, Seed | Biotech, Healthtech, Deep Tech | New fund, Aug 2026 | $3.0B (SEC Form D, 2024) | 4 Nov 2026 | 8 names · Unlock |
| Refactor Capital | VC firm | Burlingame, CA | Seed | Biotech, AI, Healthtech, Energy | New fund, May 2026 | $50M (SEC Form D, 2021) | 4 Nov 2026 | 3 names · Unlock |
| Prevail Venture Capital | VC firm | Leawood, KS | Seed | Biotech, Healthtech, Defense Tech, Fintech | New fund, Jul 2026 | $100M (SEC Form D, 2025) | 4 Nov 2026 | 8 names · Unlock |
| Bison Ventures | VC firm | San Francisco, CA | Pre-seed, Seed, Series A, Series B | Biotech, AI, Healthtech, Energy | New fund, Oct 2026 | $160M (SEC Form D, 2025) | 4 Nov 2026 | 2 names, firm email · Unlock |
| Suncoast Ventures | VC firm | Walnut Creek, CA | Seed | Biotech, Healthtech, Medtech | New fund, Jul 2026 | $15M (SEC Form D, 2022) | 4 Nov 2026 | 8 names · Unlock |
| True Ventures | VC firm | Palo Alto, CA | Pre-seed, Seed | Biotech, AI, Fintech, Deep Tech | New fund, Sep 2026 | $800M (SEC Form D, 2022) | 4 Nov 2026 | 8 names · Unlock |
| Felicis | VC firm | Menlo Park, CA | Seed, Series A | Biotech, AI, Developer Tools, Healthtech | New deal, Oct 2026 | $900M (SEC Form D, 2025) | 5 Nov 2026 | 8 names · Unlock |
| Breakout Ventures | VC firm | San Francisco, CA | Seed | Biotech, AI, Healthtech, Industrial Tech | New deal, Jun 2026 | $112M (SEC Form D, 2021) | 4 Nov 2026 | 6 names, firm email · Unlock |
| DeepWork Capital | VC firm | Orlando, FL | Seed, Series A | Biotech, Healthtech, Fintech, AI | New deal, Jun 2026 | $100M (SEC Form D, 2023) | 5 Nov 2026 | 8 names · Unlock |
| Aisling Capital | VC firm | New York, NY | Seed | Biotech, Healthtech, Food and Beverage, Medtech | Portfolio news, Jul 2026 | $64M (SEC Form ADV) | 5 Nov 2026 | 8 names · Unlock |
| Union Square Ventures | VC firm | New York, NY | Seed, Series A | Biotech, AI, Generalist, Robotics | New deal, Oct 2026 | $3M (SEC Form D, 2026) | 4 Nov 2026 | 8 names · Unlock |
| PsyMed Ventures | VC firm | Tahoma, CA | Seed | Biotech, Healthtech, AI, Medtech | New fund, Jun 2025 | $25M (SEC Form D, 2025) | 5 Nov 2026 | 5 names, firm email · Unlock |
| 2048 Ventures | VC firm | Princeton, NJ | Pre-seed, Seed | Biotech, AI, Deep Tech, Healthtech | New deal, Jun 2026 | $82M (SEC Form D, 2025) | 4 Nov 2026 | 8 names · Unlock |
| Two Bear Capital | VC firm | Whitefish, MT | Seed | Biotech, Healthtech, AI, Deep Tech | New fund, May 2026 | $123M (SEC Form D, 2025) | 4 Nov 2026 | 8 names · Unlock |
| Crossroads Health Ventures | VC firm | Indianapolis, IN | Seed | Biotech, Healthtech | New fund, Feb 2026 | $100M (SEC Form D, 2026) | 4 Nov 2026 | 4 names · Unlock |
| Cybernetix Ventures | VC firm | Boston, MA | Pre-seed, Seed, Series A | Biotech, Robotics, Industrial Tech, Logistics | New fund, Aug 2026 | $100M (SEC Form D, 2025) | 4 Nov 2026 | 2 names · Unlock |
You are seeing 25 of 159. The full list adds 134 more investors and 838 named decision-makers.
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How these 159 break down
By US state
| US state | On this list | Share |
|---|---|---|
| California | 65 | 41% |
| New York | 14 | 9% |
| Massachusetts | 14 | 9% |
| Texas | 13 | 8% |
| Florida | 10 | 6% |
| Washington | 3 | 2% |
| Illinois | 3 | 2% |
| New Jersey | 3 | 2% |
| Iowa | 3 | 2% |
| Pennsylvania | 3 | 2% |
By type
| Type | On this list | Share |
|---|---|---|
| VC firm | 158 | 99% |
| Accelerator | 1 | 1% |
Method and limits
- Source
- All 159 rows carry an SEC filing (Form D or Form ADV). All 159 have a website we checked. Filing date and fund size are SEC data where a filing exists. Stage, sector and check size are our research.
- Inclusion rule
- Organizations that back startups. Individuals, buyout funds and firms we found to be inactive are left out. Sector: the firm states biotech and life sciences as a focus on its own site, or we observed it in the firm's portfolio. Stage: the firm states that it invests at seed.
- Order
- Firms with a published profile come first. Activity score out of 100: recency of the latest fund filing or dated deal (30: full marks within 3 months, then stepping down at 6, 12 and 24 months), share of the observed portfolio in this sector (20; half of that when the sector is stated only), stage focus (15: all of it when seed is the only stage the firm states, split evenly when it states more), stated focus on the US (15: full marks when the firm names the US as where it invests, half when it says global), size of the fund on file on a log scale (12) and completeness of the public record (8). Stage and regional focus are our research, not an SEC figure. It is a measure of activity and fit, not of quality or returns.
- Last refreshed
- November 2026. Rows on this list were checked between 4 Nov 2026 and 6 Nov 2026.
- Fill rates
- Of 159 rows: stage 159, sector 159, fund size 143, website 159. In the paid file: named decision-makers on 154 rows, firm email on 47, LinkedIn page on 81, check size on 11.
- Corrections
- Email hello@theinvestordatabase.com or use the update form. We act within 5 working days.
Questions
How many seed biotech investors in the US are there?
We list 159 as of November 2026. 84 of the 159 have a fund filing or a dated deal in the last 12 months. The cities with the most are San Francisco (15), New York (10) and Palo Alto (10).
Which seed biotech investors in the US raised a new fund in the last 12 months?
58 of the 159 have a fund filing dated in the last 12 months. The most recent on this list are Future Ventures (Oct 2026), Draper Associates (Oct 2026) and Pear Ventures (Oct 2026).
What is the typical fund size of seed biotech investors in the US?
The median fund size on file for this list is $70M, across the 111 firms with a size on an SEC Form D. The fund on file is each firm's main fund, which is not always its newest. The other 48 do not disclose a size there.
How do I contact seed biotech investors in the US?
The paid file holds 838 named decision-makers across 154 of these 159 and a firm email for 47. We publish the address a firm lists itself, never a personal email. Each free row links to a profile with the firm's website.
Where does the data on seed biotech investors in the US come from?
All 159 rows have an SEC filing on file (Form D or Form ADV). Filing date and fund size come from the filing. Stage, sector and check size are our research. Rows on this list were last checked on 6 Nov 2026 at the latest. The whole file is re-verified twice a year.
Broader lists
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